Improving Properties of Podophyllic Aldehyde-Derived Cyclolignans: Design, Synthesis and Evaluation of Novel Lignohydroquinones, Dual-Selective Hybrids against Colorectal Cancer Cells

• Main Authors: Ángela-Patricia Hernández (Author), Paula Díez (Author), Pablo A. García (Author), Martín Pérez-Andrés (Author), Anzhela Veselinova (Author), Pablo G. Jambrina (Author), Arturo San Feliciano (Author), David Díez (Author), Manuel Fuentes (Author), Mᵃ Ángeles Castro (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

New lignohydroquinone conjugates (L-HQs) were designed and synthesized using the hybridization strategy, and evaluated as cytotoxics against several cancer cell lines. The L-HQs were obtained from the natural product podophyllotoxin and some semisynthetic terpenylnaphthohydroquinones, prepared from...