Engineered Human Heavy-Chain Ferritin with Half-Life Extension and Tumor Targeting by PAS and RGDK Peptide Functionalization

• Main Authors: Shuang Yin (Author), Yan Wang (Author), Bingyang Zhang (Author), Yiran Qu (Author), Yongdong Liu (Author), Sheng Dai (Author), Yao Zhang (Author), Yingli Wang (Author), Jingxiu Bi (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ferritin, one of the most investigated protein nanocages, is considered as a promising drug carrier because of its advantageous stability and safety. However, its short half-life and undesirable tumor targeting ability has limited its usage in tumor treatment. In this work, two types of functional p...