<it>SLCO1B1 </it>rs4149056 polymorphism associated with statin-induced myopathy is differently distributed according to ethnicity in the Brazilian general population: Amerindians as a high risk ethnic group
<p>Abstract</p> <p>Background</p> <p>Recent studies reported the association between <it>SLCO1B1 </it>polymorphisms and the development of statin-induced myopathy. In the scenario of the Brazilian population, being one of the most heterogeneous in the world,...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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BMC,
2011-10-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | <p>Abstract</p> <p>Background</p> <p>Recent studies reported the association between <it>SLCO1B1 </it>polymorphisms and the development of statin-induced myopathy. In the scenario of the Brazilian population, being one of the most heterogeneous in the world, the main aim here was to evaluate <it>SLCO1B1 </it>polymorphisms according to ethnic groups as an initial step for future pharmacogenetic studies.</p> <p>Methods</p> <p>One hundred and eighty-two Amerindians plus 1,032 subjects from the general urban population were included. Genotypes for the <it>SLCO1B1 </it>rs4149056 (c.T521C, p.V174A, exon 5) and <it>SLCO1B1 </it>rs4363657 (g.T89595C, intron 11) polymorphisms were detected by polymerase chain reaction followed by high resolution melting analysis with the Rotor Gene 6000<sup>® </sup>instrument.</p> <p>Results</p> <p>The frequencies of the <it>SLCO1B1 </it>rs4149056 and rs4363657 C variant allele were higher in Amerindians (28.3% and 26.1%) and were lower in African descent subjects (5.7% and 10.8%) compared with Mulatto (14.9% and 18.2%) and Caucasian descent (14.8% and 15.4%) ethnic groups (p < 0.001 and p < 0.001, respectively). Linkage disequilibrium analysis show that these variant alleles are in different linkage disequilibrium patterns depending on the ethnic origin.</p> <p>Conclusion</p> <p>Our findings indicate interethnic differences for the <it>SLCO1B1 </it>rs4149056 C risk allele frequency among Brazilians. These data will be useful in the development of effective programs for stratifying individuals regarding adherence, efficacy and choice of statin-type.</p> |
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| Item Description: | 10.1186/1471-2350-12-136 1471-2350 |