PENGARUH WAKTU PROTEKSI INFUSA BIJI Persea americana Mill. TERHADAP HEPAR DAN GINJAL TIKUS TERINDUKSI KARBONTETRAKLORIDA

• Main Authors: Lydia Setiawan (Author), Inneke Devi Permatasari (Author), Phebe Hendra (Author)
• Format: Book
• Published: Universitas Sanata Dharma, 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1693-5683; 2527-7146; 10.24071/jpsc.11168
• Keywords: Pharmacy and materia medica; RS1-441
• Source: Jurnal Farmasi Sains dan Komunitas, Vol 11, Iss 1 (2014)

Abstract: The aim of this research is to investigate the protective activity of the infusion of seed of Persea americana Mill. (IBPA) against carbon tetrachloride-induced hepatotoxicity and nephrotoxicity in rats. Healthy rats were weighed and randomly divided into 6 groups of 5 animals in each. Group 1 were treated with olive oil (2ml/kg, i.p) as negative control. Group 2 received carbon tetrachloride (2 ml/kg, i.p.). Group 3 received IBPA 360.7 mg/kg once daily for 6 hours (control of dose IBPA). Group 4-6 received IBPA at doses 360.7 mg/kg orally once for 1, 4 and 6 hours respectively received treated carbon tetrachloride. Blood sample from all groups was obtained by sinus orbitalis for the estimation serum transaminase and creatinine. The pretreatment 1,4 and 6 hours of infusion of seed of Persea americana Mill. has a potent protective activity upon carbon tetrachloride-induced hepatic and nephron damage in rats. Keywords: Persea americana Mill., infusion, protective, carbon tetrachloride