LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism

• Autori principali: Adrien Flahault (Autore), Mathilde Keck (Autore), Pierre-Emmanuel G (Autore), Lucie Esteoulle (Autore), Nadia De Mota (Autore), Dominique Bonnet (Autore), Catherine Llorens-Cortes (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and water balance, but has an in-vivo half-life in the minute range, limiting its therapeutic use. We previously developed LIT01-196, a systemically active metabolically stable apelin-17 analog, p...