α-Hederin Saponin Augments the Chemopreventive Effect of Cisplatin against Ehrlich Tumors and Bioinformatic Approach Identifying the Role of SDF1/CXCR4/p-AKT-1/NFκB Signaling

• Main Authors: Samah M. Elaidy (Author), Mohamed K. El-Kherbetawy (Author), Sally Y. Abed (Author), Abdullah Alattar (Author), Reem Alshaman (Author), Mohamed Ahmed Eladl (Author), Eman Saad Alamri (Author), Aisha Nawaf Al balawi (Author), AbdelNaser Zaid (Author), Amany Y. Elkazzaz (Author), Sozan M. Abdelkhalig (Author), Ziad E. Hamed (Author), Sawsan A. Zaitone (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Stromal cell-derived factor-1 (SDF1) and its C-X-C chemokine receptor type 4 receptor (CXCR4) are significant mediators for cancer cells' proliferation, and we studied their expression in Ehrlich solid tumors (ESTs) grown in mice. α-Hederin is a pentacyclic triterpenoid saponin found in Hedera...