Apolipoprotein E gene polymorphism, serum lipids, and risk of superficial fungal infections in Egyptian patients - A preliminary case-controlled study
Background: Apolipoprotein E (APOE) gene isoforms have been found to affect the risk of superficial fungal infections (SFIs). However, the data only cover a few ethnicities. Aims: The present work intended to investigate the association of APOE gene polymorphism and serum lipids with the susceptibil...
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Wolters Kluwer Medknow Publications,
2023-01-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_ca44d7861bd34ee68f56afa6c8fdf75a | ||
042 | |a dc | ||
100 | 1 | 0 | |a Amany I Mustafa |e author |
700 | 1 | 0 | |a Ghada M Shams |e author |
700 | 1 | 0 | |a Eman M Fawzy |e author |
700 | 1 | 0 | |a Naglaa F Alhusseini |e author |
700 | 1 | 0 | |a Rana A Khashaba |e author |
700 | 1 | 0 | |a Ola S EL-Shimi |e author |
245 | 0 | 0 | |a Apolipoprotein E gene polymorphism, serum lipids, and risk of superficial fungal infections in Egyptian patients - A preliminary case-controlled study |
260 | |b Wolters Kluwer Medknow Publications, |c 2023-01-01T00:00:00Z. | ||
500 | |a 0019-5154 | ||
500 | |a 1998-3611 | ||
500 | |a 10.4103/ijd.ijd_1001_22 | ||
520 | |a Background: Apolipoprotein E (APOE) gene isoforms have been found to affect the risk of superficial fungal infections (SFIs). However, the data only cover a few ethnicities. Aims: The present work intended to investigate the association of APOE gene polymorphism and serum lipids with the susceptibility of SFIs among a group of Egyptian patients. Materials and Methods: Standard laboratory methods were used to estimate the serum lipid profile, and polymerase chain reaction-restriction fragment length polymorphism was used to detect APOE gene polymorphism in deoxyribonucleic acid extracted from 150 SFI patients and an equal number of apparently healthy matched controls. Results: Serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol were significantly higher in the studied patients than in controls. The APOE gene ε2, ε4 alleles, and ε3/4 and ε3/2 genotypes were significantly distributed in the patients than in the controls. APOE ε3/3 genotype was predominant in dermatophytosis and tinea versicolour patients, and ε3/4 genotype was predominant in candidiasis. Conclusions: ApoE alleles ε2 and ε4, and genotypes ε2/3 and ε3/4 are linked to SFI and may be risk factors, whereas allele ε3 and genotype ε3/3 may be protective for SFI in the Egyptian population studied. The lipid profile results suggest that hyperlipidemia may provide evidence for SFI pathogenesis. However; further large-scale studies are still needed to validate our results. | ||
546 | |a EN | ||
690 | |a apolipoprotein e | ||
690 | |a gene polymorphism | ||
690 | |a superficial fungal infections | ||
690 | |a Dermatology | ||
690 | |a RL1-803 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Indian Journal of Dermatology, Vol 68, Iss 2, Pp 233-233 (2023) | |
787 | 0 | |n http://www.e-ijd.org/article.asp?issn=0019-5154;year=2023;volume=68;issue=2;spage=233;epage=233;aulast=Mustafa | |
787 | 0 | |n https://doaj.org/toc/0019-5154 | |
787 | 0 | |n https://doaj.org/toc/1998-3611 | |
856 | 4 | 1 | |u https://doaj.org/article/ca44d7861bd34ee68f56afa6c8fdf75a |z Connect to this object online. |