Apolipoprotein E gene polymorphism, serum lipids, and risk of superficial fungal infections in Egyptian patients - A preliminary case-controlled study

Background: Apolipoprotein E (APOE) gene isoforms have been found to affect the risk of superficial fungal infections (SFIs). However, the data only cover a few ethnicities. Aims: The present work intended to investigate the association of APOE gene polymorphism and serum lipids with the susceptibil...

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Main Authors: Amany I Mustafa (Author), Ghada M Shams (Author), Eman M Fawzy (Author), Naglaa F Alhusseini (Author), Rana A Khashaba (Author), Ola S EL-Shimi (Author)
Format: Book
Published: Wolters Kluwer Medknow Publications, 2023-01-01T00:00:00Z.
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001 doaj_ca44d7861bd34ee68f56afa6c8fdf75a
042 |a dc 
100 1 0 |a Amany I Mustafa  |e author 
700 1 0 |a Ghada M Shams  |e author 
700 1 0 |a Eman M Fawzy  |e author 
700 1 0 |a Naglaa F Alhusseini  |e author 
700 1 0 |a Rana A Khashaba  |e author 
700 1 0 |a Ola S EL-Shimi  |e author 
245 0 0 |a Apolipoprotein E gene polymorphism, serum lipids, and risk of superficial fungal infections in Egyptian patients - A preliminary case-controlled study 
260 |b Wolters Kluwer Medknow Publications,   |c 2023-01-01T00:00:00Z. 
500 |a 0019-5154 
500 |a 1998-3611 
500 |a 10.4103/ijd.ijd_1001_22 
520 |a Background: Apolipoprotein E (APOE) gene isoforms have been found to affect the risk of superficial fungal infections (SFIs). However, the data only cover a few ethnicities. Aims: The present work intended to investigate the association of APOE gene polymorphism and serum lipids with the susceptibility of SFIs among a group of Egyptian patients. Materials and Methods: Standard laboratory methods were used to estimate the serum lipid profile, and polymerase chain reaction-restriction fragment length polymorphism was used to detect APOE gene polymorphism in deoxyribonucleic acid extracted from 150 SFI patients and an equal number of apparently healthy matched controls. Results: Serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol were significantly higher in the studied patients than in controls. The APOE gene ε2, ε4 alleles, and ε3/4 and ε3/2 genotypes were significantly distributed in the patients than in the controls. APOE ε3/3 genotype was predominant in dermatophytosis and tinea versicolour patients, and ε3/4 genotype was predominant in candidiasis. Conclusions: ApoE alleles ε2 and ε4, and genotypes ε2/3 and ε3/4 are linked to SFI and may be risk factors, whereas allele ε3 and genotype ε3/3 may be protective for SFI in the Egyptian population studied. The lipid profile results suggest that hyperlipidemia may provide evidence for SFI pathogenesis. However; further large-scale studies are still needed to validate our results. 
546 |a EN 
690 |a apolipoprotein e 
690 |a gene polymorphism 
690 |a superficial fungal infections 
690 |a Dermatology 
690 |a RL1-803 
655 7 |a article  |2 local 
786 0 |n Indian Journal of Dermatology, Vol 68, Iss 2, Pp 233-233 (2023) 
787 0 |n http://www.e-ijd.org/article.asp?issn=0019-5154;year=2023;volume=68;issue=2;spage=233;epage=233;aulast=Mustafa 
787 0 |n https://doaj.org/toc/0019-5154 
787 0 |n https://doaj.org/toc/1998-3611 
856 4 1 |u https://doaj.org/article/ca44d7861bd34ee68f56afa6c8fdf75a  |z Connect to this object online.