Synthesis and biological evaluation of N-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2H,4H)-dione as potential antiplatelet agents

• Main Authors: Monika Marcinkowska (Author), Magdalena Kotańska (Author), Agnieszka Zagórska (Author), Joanna Śniecikowska (Author), Monika Kubacka (Author), Agata Siwek (Author), Adam Bucki (Author), Maciej Pawłowski (Author), Marek Bednarski (Author), Jacek Sapa (Author), Małgorzata Starek (Author), Monika Dąbrowska (Author), Marcin Kołaczkowski (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite the substantial clinical success of aspirin and clopidogrel in secondary prevention of ischemic stroke, up to 40% of patients remain resistant to the available antiplatelet treatment. Therefore, there is an urgent clinical need to develop novel antiplatelet agents with a novel mechanism of a...