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Quantitative analysis of inflammatory and adhesion molecules in lungs of neonates with chronic lung disease (bronchopulmonary dysplasia) receiving mechanical ventilation

ABSTRACT INTRODUCTION: Chronic lung disease (CLD), clinically known as bronchopulmonary dysplasia (BPD), is a major cause of morbidity in premature newborn and were submitted to oxygen therapy. OBJECTIVE: Immunohistochemical identification of inflammatory molecules in the lung tissue of premature ne...

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Main Authors: Cristina T. Okamoto (Author), Carlos F. Oldenburg Neto (Author), Sandra Mara Witkowski (Author), Ana Paula Percicote (Author), Luca R. Pasqualotto (Author), Gabriela Troiano (Author), Tammy Almeida (Author), Cleber M. Souza (Author), Lúcia de Noronha (Author)
Format: Book
Published: Sociedade Brasileira de Patologia Clínica.
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Summary:ABSTRACT INTRODUCTION: Chronic lung disease (CLD), clinically known as bronchopulmonary dysplasia (BPD), is a major cause of morbidity in premature newborn and were submitted to oxygen therapy. OBJECTIVE: Immunohistochemical identification of inflammatory molecules in the lung tissue of premature neonates that died with CLD. METHODS: Immunohistochemical analysis of 51 samples of premature newborn lungs - grouped in: without CLD,"classic" CLD and"new" CLD. RESULTS: Neutrophil influx and the number of CD4+ and CD45RO+ cells were higher in the"classic" CLD group (p < 0.001). CONCLUSION: Our findings suggest that the inflammatory response is mediated by neutrophils and CD45RO+ and CD4+ T lymphocytes in the"classic" CLD.
Item Description:1676-2444
1678-4774
10.5935/1676-2444.20160042

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