Ester Prodrugs of Levofloxacin to Prevent Chelate Formation in Presence of Aluminium Ion
Background: Intestinal absorption of levofloxacin (LFX) is decreased by the concomitant administration of antacids due to the formation of insoluble chelate complexes with various metal cations. Methods: The following four ester prodrugs of LFX-cilexetil ester (LFX-CLX), medoxomil ester (LFX-MDX), e...
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Tabriz University of Medical Sciences,
2023-01-01T00:00:00Z.
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