Ester Prodrugs of Levofloxacin to Prevent Chelate Formation in Presence of Aluminium Ion

• Main Authors: Yorinobu Maeda (Author), Yuka Takahashi (Author), Yuki Naika (Author), Takato Maeda (Author), Yuki Otsuka (Author), Yumi Saeki (Author), Saki Otani (Author), Kunihiko Kohama (Author), Yuhzo Hieda (Author), Takeshi Goromaru (Author), Seiji Eto (Author), Teruo Murakami (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Intestinal absorption of levofloxacin (LFX) is decreased by the concomitant administration of antacids due to the formation of insoluble chelate complexes with various metal cations. Methods: The following four ester prodrugs of LFX-cilexetil ester (LFX-CLX), medoxomil ester (LFX-MDX), e...