Modeling excess zeroes in an integrated analysis of vaccine safety

• Main Authors: Roger Maansson (Author), David Radley (Author), Qin Jiang (Author), Johannes Beeslaar (Author), Scott Patterson (Author), Judith Absalon (Author), John Perez (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In prophylactic vaccine studies in healthy populations, many subjects do not experience a single adverse event (AE). Thus, the number of AEs observed in such clinical trials may be difficult to model because of an excess of zeroes relative to the parametric distributions assumed. To determine which...