Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study

• Autores principales: Joël Pincemail (Autor), Etienne Cavalier (Autor), Corinne Charlier (Autor), Jean-Paul Cheramy-Bien (Autor), Eric Brevers (Autor), Audrey Courtois (Autor), Marjorie Fadeur (Autor), Smail Meziane (Autor), Caroline Le Goff (Autor), Benoît Misset (Autor), Adelin Albert (Autor), Jean-Olivier Defraigne (Autor), Anne-Françoise Rousseau (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2021-02-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Sumario

Background: A key role of oxidative stress has been highlighted in the pathogenesis of COVID-19. However, little has been said about oxidative stress status (OSS) of COVID-19 patients hospitalized in intensive care unit (ICU). Material and Methods: Biomarkers of the systemic OSS included antioxidants (9 assays), trace elements (3 assays), inflammation markers (4 assays) and oxidative damage to lipids (3 assays). Results: Blood samples were drawn after 9 (7-11) and 41 (39-43) days of ICU stay, respectively in 3 and 6 patients. Vitamin C, thiol proteins, reduced glutathione, γ-tocopherol, β-carotene and PAOT^® score were significantly decreased compared to laboratory reference values. Selenium concentration was at the limit of the lower reference value. By contrast, the copper/zinc ratio (as a source of oxidative stress) was higher than reference values in 55% of patients while copper was significantly correlated with lipid peroxides (r = 0.95, <i>p</i> < 0.001). Inflammatory biomarkers (C-reactive protein and myeloperoxidase) were significantly increased when compared to normals. Conclusions: The systemic OSS was strongly altered in critically ill COVID-19 patients as evidenced by increased lipid peroxidation but also by deficits in some antioxidants (vitamin C, glutathione, thiol proteins) and trace elements (selenium).

Notas

10.3390/antiox10020257
2076-3921