Elucidation of possible mechanisms of the antidiabetic potential of Zn-loaded Bryophyllum pinnatum (Lam.) extracts in experimental animal models
Abstract Background The present study focused on the antidiabetic potential and fingerprinting analysis of Bryophyllumc pinnatum stems as well as its possible mechanisms of action along with identification of its major phytoconstituents. The oral glucose tolerance test has been performed administeri...
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2022-10-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_ca7d386312b24e41a6dc1e17b3c24aaf | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Varsha Tiwari |e author |
| 700 | 1 | 0 | |a Abhishek Tiwari |e author |
| 700 | 1 | 0 | |a Anita Singh |e author |
| 700 | 1 | 0 | |a Navneet Verma |e author |
| 700 | 1 | 0 | |a Manish Kumar |e author |
| 700 | 1 | 0 | |a Ajay Sharma |e author |
| 245 | 0 | 0 | |a Elucidation of possible mechanisms of the antidiabetic potential of Zn-loaded Bryophyllum pinnatum (Lam.) extracts in experimental animal models |
| 260 | |b SpringerOpen, |c 2022-10-01T00:00:00Z. | ||
| 500 | |a 10.1186/s43094-022-00431-7 | ||
| 500 | |a 2314-7253 | ||
| 520 | |a Abstract Background The present study focused on the antidiabetic potential and fingerprinting analysis of Bryophyllumc pinnatum stems as well as its possible mechanisms of action along with identification of its major phytoconstituents. The oral glucose tolerance test has been performed administering a glucose solution (2000 mg/kg) to induce hyperglycemia. Diabetes have been instigated by single intra-peritoneal injection of streptozotocin (65 mg/kg). Results Alcohol and aqueous extracts were found to be safe up to a dose of 3000 mg/kg. Oral glucose tolerance test results showed significant reduction in fasting blood glucose level. Alcohol and aqueous extracts (200, 400 mg/kg b.w.) showed significant reduction in fasting blood glucose among all groups. Groups receiving zinc sulfate-loaded extracts showed a statistically significant reduction in low-density lipoproteins, triglycerides and total cholesterol levels and enhanced levels of high density lipoproteins. Fingerprinting analysis has been performed to identify the major phytoconstituents of flavonoid category morin, chrysin, and 6-hydroxy flavones, as well as iso-quercetin, hyperosides and terpenoids present in the extracts possess antidiabetic potential. Conclusions Both alcohol and aqueous extracts found to possess significant antidiabetic activity in diabetic rats. Zinc sulfate synergistically potentiates the antidiabetic potential of alcohol extract. Fingerprinting analysis revealed the presence of flavonoids such as morin, chrysin, and 6-hydroxy flavones, as well as iso-quercetin, hyperosides, and terpenoids. The possible mechanisms of antidiabetic activity have been elucidated, although further studies are required to give more elaborated mechanism on molecular basis. Graphical abstract | ||
| 546 | |a EN | ||
| 690 | |a Fingerprinting | ||
| 690 | |a OGTT | ||
| 690 | |a Streptozotocin | ||
| 690 | |a Fasting blood glucose level | ||
| 690 | |a Anti-diabetic | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Future Journal of Pharmaceutical Sciences, Vol 8, Iss 1, Pp 1-19 (2022) | |
| 787 | 0 | |n https://doi.org/10.1186/s43094-022-00431-7 | |
| 787 | 0 | |n https://doaj.org/toc/2314-7253 | |
| 856 | 4 | 1 | |u https://doaj.org/article/ca7d386312b24e41a6dc1e17b3c24aaf |z Connect to this object online. |