Vaccination with single plasmid DNA encoding IL-12 and antigens of severe fever with thrombocytopenia syndrome virus elicits complete protection in IFNAR knockout mice.

• Main Authors: Jun-Gu Kang (Author), Kyeongseok Jeon (Author), Hooncheol Choi (Author), Yuri Kim (Author), Hong-Il Kim (Author), Hyo-Jin Ro (Author), Yong Bok Seo (Author), Jua Shin (Author), Junho Chung (Author), Yoon Kyung Jeon (Author), Yang Soo Kim (Author), Keun Hwa Lee (Author), Nam-Hyuk Cho (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by SFTS virus (SFTSV) infection. Despite a gradual increase of SFTS cases and high mortality in endemic regions, no specific viral therapy nor vaccine is available. Here, we developed a single recombinant pla...