Growth, tolerance and safety outcomes with use of an extensively hydrolyzed casein-based formula in infants with cow's milk protein allergy

• Main Authors: Aydan Kansu (Author), Nafiye Urganci (Author), Aysegul Bukulmez (Author), Gunsel Kutluk (Author), Didem Gulcu Taskin (Author), Lutfiye Sahin Keskin (Author), Mahir Igde (Author), Lutfi Molon (Author), Yasar Dogan (Author), Bulent Enis Sekerel (Author), Mutlu Yuksek (Author), Ilknur Bostanci (Author), Nelgin Gerenli (Author), Esra Polat (Author), Buket Dalgic (Author), Hasret Ayyildiz (Author), Merve Usta (Author), Ahmet Basturk (Author), Ozlem Yuce Kirmemis (Author), Ceyda Tuna Kirsaclioglu (Author), Hacer Fulya Gulerman (Author), Aysugul Alptekin Sarioglu (Author), Simge Erdogan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2296-2360; 10.3389/fped.2023.1230905
• Keywords: cow's milk protein allergy; extensively hydrolyzed casein-based formula; growth indices; gastrointestinal intolerance; stool patterns; parental satisfaction; Pediatrics; RJ1-570
• Source: Frontiers in Pediatrics, Vol 11 (2023)

ObjectiveTo evaluate growth, tolerance and safety outcomes with use of an extensively hydrolyzed casein-based formula (eHCF) in infants with cow's milk protein allergy (CMPA).MethodsA total of 226 infants (mean ± SD age: 106.5 ± 39.5 days, 52.7% were girls) with CMPA who received eHCF comprising at least half of the daily dietary intake were included. Data on anthropometrics [weight for age (WFA), length for age (LFA) and weight for length (WFL) z-scores] were recorded at baseline (visit 1), while data on infant feeding and stool records, anthropometrics and Infant Feeding and Stool Patterns and Formula Satisfaction Questionnaires were recorded at visit 2 (on Days 15 ± 5) and visit 3 (on Days 30 ± 5).ResultsFrom baseline to visit 2 and visit 3, WFA z-scores (from −0.60 ± 1.13 to −0.54 ± 1.09 at visit 2, and to −0.44 ± 1.05 at visit 3, p < 0.001) and WFL z-scores (from −0.80 ± 1.30 to −0.71 ± 1.22 at visit 2, and to −0.64 ± 1.13 at visit 3, p = 0.002) were significantly increased. At least half of infants never experienced irritability or feeding refusal (55.7%) and spit-up after feeding (50.2%). The majority of mothers were satisfied with the study formula (93.2%), and wished to continue using it (92.2%).ConclusionsIn conclusion, eHCF was well-accepted and tolerated by an intended use population of infants ≤ 6 months of age with CMPA and enabled adequate volume consumption and improved growth indices within 30 days of utilization alongside a favorable gastrointestinal tolerance and a high level of parental satisfaction.