Novel Iron Chelators, Super-Polyphenols, Show Antimicrobial Effects against Cariogenic <i>Streptococcus mutans</i>
Dental caries are an oral infectious disease that can affect human health both orally and systemically. It remains an urgent issue to establish a novel antibacterial method to prevent oral infection for a healthy life expectancy. The aim of this study was to evaluate the inhibitory effects of novel...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
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MDPI AG,
2023-10-01T00:00:00Z.
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| Summary: | Dental caries are an oral infectious disease that can affect human health both orally and systemically. It remains an urgent issue to establish a novel antibacterial method to prevent oral infection for a healthy life expectancy. The aim of this study was to evaluate the inhibitory effects of novel iron chelators, super-polyphenols (SPs), on the cariogenic bacterium <i>Streptococcus mutans</i>, in vitro. SPs were developed to reduce the side effects of iron chelation therapy and were either water-soluble or insoluble depending on their isoforms. We found that SP6 and SP10 inhibited bacterial growth equivalent to povidone-iodine, and viability tests indicated that their effects were bacteriostatic. These results suggest that SP6 and SP10 have the potential to control oral bacterial infections such as <i>Streptococcus mutans</i>. |
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| Item Description: | 10.3390/antibiotics12111562 2079-6382 |