Novel Iron Chelators, Super-Polyphenols, Show Antimicrobial Effects against Cariogenic <i>Streptococcus mutans</i>
Dental caries are an oral infectious disease that can affect human health both orally and systemically. It remains an urgent issue to establish a novel antibacterial method to prevent oral infection for a healthy life expectancy. The aim of this study was to evaluate the inhibitory effects of novel...
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| Format: | Book |
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MDPI AG,
2023-10-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_cac874b8c2b34d7293e799e0f83a2b9f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Yuki Shinoda-Ito |e author |
| 700 | 1 | 0 | |a Kazuhiro Omori |e author |
| 700 | 1 | 0 | |a Takashi Ito |e author |
| 700 | 1 | 0 | |a Masaaki Nakayama |e author |
| 700 | 1 | 0 | |a Atsushi Ikeda |e author |
| 700 | 1 | 0 | |a Masahiro Ito |e author |
| 700 | 1 | 0 | |a Toshiaki Ohara |e author |
| 700 | 1 | 0 | |a Shogo Takashiba |e author |
| 245 | 0 | 0 | |a Novel Iron Chelators, Super-Polyphenols, Show Antimicrobial Effects against Cariogenic <i>Streptococcus mutans</i> |
| 260 | |b MDPI AG, |c 2023-10-01T00:00:00Z. | ||
| 500 | |a 10.3390/antibiotics12111562 | ||
| 500 | |a 2079-6382 | ||
| 520 | |a Dental caries are an oral infectious disease that can affect human health both orally and systemically. It remains an urgent issue to establish a novel antibacterial method to prevent oral infection for a healthy life expectancy. The aim of this study was to evaluate the inhibitory effects of novel iron chelators, super-polyphenols (SPs), on the cariogenic bacterium <i>Streptococcus mutans</i>, in vitro. SPs were developed to reduce the side effects of iron chelation therapy and were either water-soluble or insoluble depending on their isoforms. We found that SP6 and SP10 inhibited bacterial growth equivalent to povidone-iodine, and viability tests indicated that their effects were bacteriostatic. These results suggest that SP6 and SP10 have the potential to control oral bacterial infections such as <i>Streptococcus mutans</i>. | ||
| 546 | |a EN | ||
| 690 | |a antimicrobial | ||
| 690 | |a iron chelator | ||
| 690 | |a oral infection | ||
| 690 | |a <i>Streptococcus mutans</i> | ||
| 690 | |a super-polyphenols | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Antibiotics, Vol 12, Iss 11, p 1562 (2023) | |
| 787 | 0 | |n https://www.mdpi.com/2079-6382/12/11/1562 | |
| 787 | 0 | |n https://doaj.org/toc/2079-6382 | |
| 856 | 4 | 1 | |u https://doaj.org/article/cac874b8c2b34d7293e799e0f83a2b9f |z Connect to this object online. |