Acoustically Driven Cell-Based Microrobots for Targeted Tumor Therapy

• Main Authors: Hiep Xuan Cao (Author), Van Du Nguyen (Author), Daewon Jung (Author), Eunpyo Choi (Author), Chang-Sei Kim (Author), Jong-Oh Park (Author), Byungjeon Kang (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/pharmaceutics14102143; 1999-4923
• Keywords: acoustic manipulation; cell-based microrobot; targeted drug delivery; Pharmacy and materia medica; RS1-441
• Source: Pharmaceutics, Vol 14, Iss 10, p 2143 (2022)

Targeted drug delivery using microrobots manipulated by an external actuator has significant potential to be a practical approach for wireless delivery of therapeutic agents to the targeted tumor. This work aimed to develop a novel acoustic manipulation system and macrophage-based microrobots (Macbots) for a study in targeted tumor therapy. The Macbots containing superparamagnetic iron oxide nanoparticles (SPIONs) can serve as drug carriers. Under an acoustic field, a microrobot cluster of the Macbots is manipulated by following a predefined trajectory and can reach the target with a different contact angle. As a fundamental validation, we investigated an in vitro experiment for targeted tumor therapy. The microrobot cluster could be manipulated to any point in the 4 × 4 × 4 mm region of interest with a position error of less than 300 μm. Furthermore, the microrobot could rotate in the O-XY plane with an angle step of 45 degrees without limitation of total angle. Finally, we verified that the Macbots could penetrate a 3D tumor spheroid that mimics an in vivo solid tumor. The outcome of this study suggests that the Macbots manipulated by acoustic actuators have potential applications for targeted tumor therapy.