The State of the Immune System in Сhildren with Bronchial Asthma who are at the Stage of Balneological Rehabilitation

• Main Authors: N. N. Kaladze (Author), A. I. Ezernitskaya (Author), M. L. Babak (Author)
• Format: Book
• Published: LLC "Diagnostics and Vaccines", 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2072-8107; 10.22627/2072-8107-2018-17-4-12-17
• Keywords: bronchial asthma; children; immunity; 2b-interferon; balneological treatment; Pediatrics; RJ1-570
• Source: Детские инфекции (Москва), Vol 17, Iss 4, Pp 12-17 (2018)

Decrease in a-interferon (IFN-a) levels by 6.8% (p > 0.05) compared to the control group, IFN-g by 37.7% (p < 0.05), relative quantity of CD8 + lymphocytes - by 12.26% (p < 0.001) and an increase in the relative amount of CD4 + lymphocytes by 3.9% and CD95 + lymphocytes by 49.73% (p < 0.01), IgE levels 4.1 - fold (p < 0.001) and IL-4 - on 30% it was revealed in 36 children with bronchial asthma, who came to sanatorium-and-spa treatment. An increase in IFN-a levels by 74.7% (p < 0.01) compared with baseline, IFN-g 2.1 - fold (p < 0.001), relative CD8 + lymphocyte count - by 12.26% (p < 0.001) and a significant decrease in the relative amount of CD4 + lymphocytes - by 4.8% (p < 0.05) and CD95 + lymphocytes - by 23.84% (p < 0.01), IgE levels by 28.1% (p < 0.01) and IL-4 - 2.3 times observed after the using a drug containing a2b-interferon and antioxidants vitamins E and C - VIFERON® in the process of balneological treatment.