Dual-responsive chondroitin sulfate self-assembling nanoparticles for combination therapy in metastatic cancer cells

• Main Authors: Ensieh Poursani (Author), Giuseppe Cirillo (Author), Manuela Curcio (Author), Orazio Vittorio (Author), Michele De Luca (Author), Antonella Leggio (Author), Fiore Pasquale Nicoletta (Author), Francesca Iemma (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we developed self-assembling nanoparticles (LCPs) able to trigger the release of Chlorambucil (Chl) and Doxorubicin (DOX) to MDA-MB-231 cells by exploiting the enzyme and redox signals. The DOX loaded LCPs was prepared by the self-assembly of two chondroitin sulphate (CS) derivatives,...