2'-Fucosyllactose Is Well Tolerated in a 100% Whey, Partially Hydrolyzed Infant Formula With : A Randomized Controlled Trial

• Main Authors: Heidi M. Storm MS, RD (Author), Julie Shepard MD (Author), Laura M. Czerkies MS, RD (Author), Brian Kineman PhD (Author), Sarah S. Cohen MS, PhD (Author), Heidi Reichert MA (Author), Ryan Carvalho MD (Author)
• Format: Book
• Published: SAGE Publishing, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Human milk oligosaccharides are important components of breast milk. We evaluated feeding tolerance of the human milk oligosaccharide 2'-fucosyllactose (2'FL) in a 100% whey, partially hydrolyzed infant formula with the probiotic Bifidobacterium animalis ssp lactis strain Bb12 ( B lactis ; Test) as compared with the same formula without 2'FL (Control) in a randomized controlled trial of healthy infants enrolled at 2 weeks of age (±5 days). After 6 weeks of feeding the assigned formula, the primary outcome of tolerance was assessed using the Infant Gastrointestinal Symptom Questionnaire. Stooling, vomiting, spit-up, crying, and fussing were compared between groups. Seventy-nine infants were enrolled and 63 completed the study per protocol (30 Test, 33 Control). Infant Gastrointestinal Symptom Questionnaire scores were similar between groups (Test 20.9 ± 4.8, Control 20.7 ± 4.3, P = .82). Partially hydrolyzed infant formula with 2'FL and B lactis is tolerated well, as confirmed by a validated multi-symptom index.

Item Description

2333-794X
10.1177/2333794X19833995