Association of T352C and A16974C polymorphisms with lepromatose leprosy in Cuban patients

• Main Authors: Estela Morales Peralta (Author), Yadira Hernández Pérez (Author), Kilenda Peñalver Morales (Author), Yulié Lamas Torres (Author), Raisa Rumbaut Castillo (Author), Teresa Collazo Mesa (Author)
• Format: Book
• Published: Universidad de Ciencias Médicas de La Habana, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p style="margin-bottom: .0001pt; text-align: justify; line-height: 150%;"><span style="color: #000000; font-family: verdana; font-size: small;"><strong>Introduction:</strong> Leprosy is an infectious disease caused by <em>Mycobacterium leprae</em>. Dermatoglyphic patterns of Cuban patients with lepromatose leprosy showed evidential signs of the existence of genetic predisposition to the development of this disease, which suggests a search for the association with molecular polymorphisms of higher degree of accuracy. Among them, some of the most studied are the T352C vitamin D receptor gene and the A16974Cof the IL12p40 gene, which relative usefulness depends on the population. </span></p><p style="margin-bottom: .0001pt; text-align: justify; line-height: 150%;"><span style="color: #000000; font-family: verdana; font-size: small;"><strong>Objective:</strong>To determine whether there is an association between the T352Cand A16974C polymorphisms with lepromatose leprosy in Cuban patients.</span></p><p style="margin-bottom: .0001pt; text-align: justify; line-height: 150%;"><span style="color: #000000; font-family: verdana; font-size: small;"><strong>Material and methods:</strong>An observational analytical case-control type genetic association study was conducted where patients with lepromatose leprosy and controls were studied. Genotypes related to T352Cand A16974C polymorphisms were identified in each group.  Pearson´s chi square test was used to determine whether the controls were in Hardy-Weinberg equilibrium, and also whether there was a relation between polymorphisms and the presence of diseases. <strong></strong></span></p><p style="margin-bottom: .0001pt; text-align: justify; line-height: 150%;"><span style="color: #000000; font-family: verdana; font-size: small;"><strong>Results:</strong> There were 32 patients under study for T352C polymorphism, and 42 for A16974C. The controls were 64 and 44, respectively; and these were in Hardy-Weinberg equilibrium.  No association between T352Cand A16974C polymorphisms with lepromatose leprosy was detected. </span></p><p style="margin-bottom: .0001pt; text-align: justify; line-height: 150%;"><span style="color: #000000; font-family: verdana; font-size: small;"><strong>Conclusions: </strong> T352Cand A16974C polymorphisms are not useful as a predisposing risk factor in the group of Cuban patients with lepromatose leprosy studied.</span></p><p style="text-align: justify; line-height: 150%;"><span style="color: #000000; font-family: verdana; font-size: small;"><strong>Keywords:</strong> Leprosy, genetic polymorphism, genetic predisposition to disease, Cuba, Hardy-Weinberg equilibrium, alleles.</span></p>

Item Description

1729-519X