Targeted Thrombolytic Enzymes Delivery

The intravascular delivery of thrombolytic medicines is required due to the small molecular sizes of the medications, resulting in systemic effects and the induction of the lytic state. Although the dose of tPA is higher than that encountered by a healthy organism, it is only partly provided (0.9 mg...

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Xehetasun bibliografikoak
Egile nagusia: Taimoor Hassan (Egilea)
Formatua: Liburua
Argitaratua: ziauddin University, 2024-05-01T00:00:00Z.
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100 1 0 |a Taimoor Hassan  |e author 
245 0 0 |a Targeted Thrombolytic Enzymes Delivery 
260 |b ziauddin University,   |c 2024-05-01T00:00:00Z. 
500 |a 10.36283/PJMD11-2/001 
500 |a 2313-7371 
500 |a 2308-2593 
520 |a The intravascular delivery of thrombolytic medicines is required due to the small molecular sizes of the medications, resulting in systemic effects and the induction of the lytic state. Although the dose of tPA is higher than that encountered by a healthy organism, it is only partly provided (0.9 mg/kg for stroke, not more than 90 mg and100 mg for myocardial infarction) due to the rapid degradation of tPA upon delivery. Its blood lodging period is just a few minutes, as opposed to the newer type (Tenecteplase, TNKase®), which has a somewhat longer time to lodge blood.  
546 |a EN 
690 |a Biochemistry 
690 |a QD415-436 
690 |a Dentistry 
690 |a RK1-715 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
690 |a Medicine (General) 
690 |a R5-920 
655 7 |a article  |2 local 
786 0 |n Pakistan Journal of Medicine and Dentistry, Vol 11, Iss 2 (2024) 
787 0 |n https://ojs.zu.edu.pk/pjmd/article/view/1598 
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787 0 |n https://doaj.org/toc/2308-2593 
856 4 1 |u https://doaj.org/article/cbef35f036a44f1d9c8a7783bbab1ee6  |z Connect to this object online.