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Utility of hybrid whole genome sequencing in assessing potential nosocomial VIM transmission

Hybrid whole genome sequencing was used to investigate if nosocomial Verona integron-encoded metallo-β-lactamase (VIM) carbapenemase transmission occurred between two patients without epidemiological links or common pathogens. Challenges in genomic methodology and appropriate analytical depth for mo...

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Bibliographic Details
Main Authors: David Burke James Mahoney (Author), Xena Li (Author), Patryk Aftanas (Author), Christie Vermeiren (Author), Robert Kozak (Author), Kevin Katz (Author), Finlay Maguire (Author)
Format: Book
Published: Cambridge University Press, 2024-01-01T00:00:00Z.
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Summary:Hybrid whole genome sequencing was used to investigate if nosocomial Verona integron-encoded metallo-β-lactamase (VIM) carbapenemase transmission occurred between two patients without epidemiological links or common pathogens. Challenges in genomic methodology and appropriate analytical depth for mobile carbapenemase outbreaks are described including how inappropriate choices can mislead results and impact infection control practices.
Item Description:10.1017/ash.2024.347
2732-494X

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