Repositioning of Etravirine as a Potential CK1ε Inhibitor by Virtual Screening

• Main Authors: Luis Córdova-Bahena (Author), Axel A. Sánchez-Álvarez (Author), Angel J. Ruiz-Moreno (Author), Marco A. Velasco-Velázquez (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CK1ε is a key regulator of WNT/β-catenin and other pathways that are linked to tumor progression; thus, CK1ε is considered a target for the development of antineoplastic therapies. In this study, we performed a virtual screening to search for potential CK1ε inhibitors. First, we characterized the dy...