HLA typing in Taiwanese patients with oral squamous cell carcinoma

• Main Authors: Chia-Chun Lu (Author), Tréjaut John (Author), Chieh-Yuan Cheng (Author), Chu-Sheng Lin (Author), Chung-Ji Liu (Author)
• Format: Book
• Published: Elsevier, 2014-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1991-7902; 10.1016/j.jds.2013.02.005
• Keywords: head and neck cancer; HLA alleles; polymorphism; sequencing-based typing; Dentistry; RK1-715
• Source: Journal of Dental Sciences, Vol 9, Iss 1, Pp 41-48 (2014)

Background/purpose: The human leukocyte antigen (HLA) system, which plays a vital role in immunity, is the most polymorphic gene complex found in the human genome. This study investigated HLA-related alleles and haplotypes in Taiwanese patients with oral squamous cell carcinoma (OSCC). Materials and methods: HLA class I (HLA-A and HLA-B) antigens and class II (HLA-DRB1) alleles were determined in 105 patients with OSCC and compared with those in 190 healthy controls. The antigens were measured serologically and the alleles by sequencing-based typing. Results: Compared with the control group, patients with OSCC had higher frequencies of HLA-A24, HLA-B54, HLA-DRB1*0405, and HLA-DRB1*1201, while they had lower frequencies of HLA-B58 and HLA-DRB1*1302. Haplotype frequencies also varied significantly in individuals with OSCC, with certain haplotypes associated with lymph node metastases or a particular tumor stage. Conclusion: These results suggest that HLA genetic factors influence susceptibility to OSCC and perhaps to lymph node metastasis and tumor progression.