Targeted intracellular delivery of dimeric STINGa by two pHLIP peptides for treatment of solid tumors

• Main Authors: Anna Moshnikova (Author), Michael DuPont (Author), Marissa Iraca (Author), Craig Klumpp (Author), Hannah Visca (Author), Dana Allababidi (Author), Phoebe Pelzer (Author), Donald M. Engelman (Author), Oleg A. Andreev (Author), Yana K. Reshetnyak (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: We have developed a delivery approach that uses two pHLIP peptides that collaborate in the targeted intracellular delivery of a single payload, dimeric STINGa (dMSA).Methods: dMSA was conjugated with two pHLIP peptides via S-S cleavable self-immolating linkers to form 2pHLIP-dMSA.Resul...