Experience of anti-adhesion barrier in the complex therapy of patients with uterine factor infertility
<p> N.I. Nasyrova<sup>1,2</sup>, Yu.E. Dobrokhotova<sup>2</sup>, L.A. Ozolinya<sup>2</sup>, M.Z. Argun<sup>1</sup>, K.V. Mirskaya<sup>1</sup> </p> <p> <sup>1</sup>Central Clinical Hospital of Civil Aviation, Mo...
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LCC «Medicine-Inform»,
2023-12-01T00:00:00Z.
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| Summary: | <p> N.I. Nasyrova<sup>1,2</sup>, Yu.E. Dobrokhotova<sup>2</sup>, L.A. Ozolinya<sup>2</sup>, M.Z. Argun<sup>1</sup>, K.V. Mirskaya<sup>1</sup> </p> <p> <sup>1</sup>Central Clinical Hospital of Civil Aviation, Moscow, Russian Federation </p> <p> <sup>2</sup>Pirogov Russian National Research Medical University, Moscow, Russian Federation </p> <p> <b>Aim: </b>to determine the efficacy of hyaluronic acid anti-adhesion barrier in the complex therapy of uterine factor infertility. </p> <p> <b>Patients and Methods: </b>the retrospective study included data from 95 female patients aged 23 to 39 years with various forms of intrauterine pathology. Female patients were divided into 2 groups: group 1 (n=36) - intraoperative injection of hyaluronic acid anti-adhesion barrier into the uterine cavity, group 2 (n=59) - no injection of gel. All patients underwent surgical treatment according to the generally accepted recommendations. Transvaginal ultrasound, analyzing the endometrial thickness and structure, was performed 3 months after the surgery. After conducting the corresponding complex treatment, the pregnancy frequency was evaluated for 24 months. </p> <p> <b>Results: </b>in the post-surgical period in group 1, there was a normal echographic endometrial image observed in 30 (83.3%) female patients, and in 6 (16.7%) there were indirect signs of chronic endometritis. In group 2, only 16 (27.1%) female patients had a normal echographic picture, while 15 (25.4%) showed signs of chronic endometritis, and 14 (23.7%) had the intrauterine adhesions, indicated a high probability of intrauterine synechiae recurrence without the use of an anti-adhesion barrier. The total number of female patients who implemented reproductive life planning was 28 (77.8%) in group 1 and 31 (52.5%) in group 2 (p<0.05). </p> <p> <b>Conclusion: </b>it was shown that there was a high risk of intrauterine synechiae after intrauterine interventions with subsequent disorder of reproductive function. The use of hyaluronic acid anti-adhesion barrier during intrauterine surgical interventions can be considered as prevention of intrauterine post-surgical adhesions. The administration of hyaluronic acid anti-adhesion barrier into the uterine cavity significantly improved the reproductive prognosis in female patients with uterine factor infertility. </p> <p> <b>Keywords:</b> infertility, uterine factor infertility, intrauterine synechiae, anti-adhesion barrier, hyaluronic acid. </p> <p> <b>For citation:</b> Nasyrova N.I., Dobrokhotova Yu.E., Ozolinya L.A., Argun M.Z., Mirskaya K.V. Experience of anti-adhesion barrier in the complex therapy of patients with uterine factor infertility. Russian Journal of Woman and Child Health. 2023;6(4):326-331 (in Russ.). DOI: 10.32364/2618-8430-2023-6-4-1. </p> <br> |
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| Item Description: | 2618-8430 2686-7184 |