Aptamer-iRNAs as Therapeutics for Cancer Treatment

• Main Authors: Mario M. Soldevilla (Author), Daniel Meraviglia-Crivelli de Caso (Author), Ashwathi P. Menon (Author), Fernando Pastor (Author)
• Format: Book
• Published: MDPI AG, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aptamers are single-stranded oligonucleotides (ssDNA or ssRNA) that bind and recognize their targets with high affinity and specificity due to their complex tertiary structure. Aptamers are selected by a method called SELEX (Systematic Evolution of Ligands by EXponential enrichment). This method has...