Minimal-length Synthetic shRNAs Formulated with Lipid Nanoparticles are Potent Inhibitors of Hepatitis C Virus IRES-linked Gene Expression in Mice

• Main Authors: Anne Dallas (Author), Heini Ilves (Author), Joshua Shorenstein (Author), Adam Judge (Author), Ryan Spitler (Author), Christopher Contag (Author), Suet Ping Wong (Author), Richard P Harbottle (Author), Ian MacLachlan (Author), Brian H Johnston (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously identified short synthetic shRNAs (sshRNAs) that target a conserved hepatitis C virus (HCV) sequence within the internal ribosome entry site (IRES) of HCV and potently inhibit HCV IRES-linked gene expression. To assess in vivo liver delivery and activity, the HCV-directed sshRNA, SG220...