Dietary intake of glucoraphanin during pregnancy and lactation prevents the behavioral abnormalities in the offspring after maternal immune activation

Abstract Aim Epidemiological data suggest that maternal immune activation (MIA) plays a role in the etiology of neuropsychiatric disorders including autism spectrum disorder (ASD) and schizophrenia. However, there is no prophylactic nutrition that can prevent the onset of neurodevelopmental disorder...

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Main Authors: Yuko Fujita (Author), Atsuhiro Fujita (Author), Tamaki Ishima (Author), Ayumi Hirai (Author), Shigenori Suzuki (Author), Hiroyuki Suganuma (Author), Kenji Hashimoto (Author)
Format: Book
Published: Wiley, 2020-09-01T00:00:00Z.
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LEADER 00000 am a22000003u 4500
001 doaj_cc564a2abe3f42da90cae22e4ffa6bf4
042 |a dc 
100 1 0 |a Yuko Fujita  |e author 
700 1 0 |a Atsuhiro Fujita  |e author 
700 1 0 |a Tamaki Ishima  |e author 
700 1 0 |a Ayumi Hirai  |e author 
700 1 0 |a Shigenori Suzuki  |e author 
700 1 0 |a Hiroyuki Suganuma  |e author 
700 1 0 |a Kenji Hashimoto  |e author 
245 0 0 |a Dietary intake of glucoraphanin during pregnancy and lactation prevents the behavioral abnormalities in the offspring after maternal immune activation 
260 |b Wiley,   |c 2020-09-01T00:00:00Z. 
500 |a 2574-173X 
500 |a 10.1002/npr2.12112 
520 |a Abstract Aim Epidemiological data suggest that maternal immune activation (MIA) plays a role in the etiology of neuropsychiatric disorders including autism spectrum disorder (ASD) and schizophrenia. However, there is no prophylactic nutrition that can prevent the onset of neurodevelopmental disorders in offspring after MIA. The aim of this study was undertaken to examine whether dietary intake of glucoraphanin (GF: the precursor of a natural anti‐inflammatory compound sulforaphane) can prevent the onset of behavioral abnormalities in offspring after MIA. Methods One percent of GF food pellet or normal food pellet was given into female mice during pregnancy and lactation (from E5 to P21). Saline (5 mL/kg/d) or poly(I:C) (5 mg/kg/d) was injected into pregnant mice from E12 to E17. Behavioral tests and immunohistochemistry of parvalbumin (PV) were performed in male offspring. Results Dietary intake of GF during pregnancy and lactation prevented cognitive deficits and social interaction deficits in the juvenile offspring after MIA. Furthermore, dietary intake of GF during pregnancy and lactation prevented cognitive deficits in the adult offspring after MIA. Moreover, dietary intake of GF prevented the reduction of PV immunoreactivity in the medial prefrontal cortex of adult offspring after MIA. Conclusion These data suggest that dietary intake of GF during pregnancy and lactation could prevent behavioral abnormalities in offspring after MIA. 
546 |a EN 
690 |a autism 
690 |a glucoraphanin 
690 |a nutrition 
690 |a prevention 
690 |a schizophrenia 
690 |a sulforaphane 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
690 |a Neurosciences. Biological psychiatry. Neuropsychiatry 
690 |a RC321-571 
655 7 |a article  |2 local 
786 0 |n Neuropsychopharmacology Reports, Vol 40, Iss 3, Pp 268-274 (2020) 
787 0 |n https://doi.org/10.1002/npr2.12112 
787 0 |n https://doaj.org/toc/2574-173X 
856 4 1 |u https://doaj.org/article/cc564a2abe3f42da90cae22e4ffa6bf4  |z Connect to this object online.