Association of Age and BP Variability with Long-term Mortality in Hemodialysis Patients

• Main Authors: Ha Yeon Kim (Author), Yong Un Kang (Author), Chang Seong Kim (Author), Joon Seok Choi (Author), Eun Hui Bae (Author), Seong Kwon Ma (Author), Soo Wan Kim (Author)
• Format: Book
• Published: Karger Publishers, 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1420-4096; 1423-0143; 10.1159/000355765
• Keywords: Age; Blood pressure variability; Dialysis; Dermatology; RL1-803; Diseases of the circulatory (Cardiovascular) system; RC666-701; Diseases of the genitourinary system. Urology; RC870-923
• Source: Kidney & Blood Pressure Research, Vol 38, Iss 2-3, Pp 172-180 (2014)

Background/Aims: Blood pressure (BP) variability is known as a poor prognostic factor for cardiovascular outcomes. This study assessed the prognostic significance of BP variability in association with increasing age in hemodialysis patients. Methods: We retrospectively analyzed 2,174 patients on hemodialysis from March 2005 to December 2012. The impact of intradialytic and interdialytic BP variability on all-cause mortality according to age groups was analyzed. Results: Kaplan-Meier survival curves for 5-year cumulative mortality showed higher mortality in patients with higher intradialytic systolic and diastolic BP variability as well as interdialytic systolic and diastolic BP variability (log-rank p=0.006, Conclusion: The overall mortality was associated with BP variability in patients aged <55 years, but not in older ages. This result suggests that younger hemodialysis patients with BP variability require further medical attention and intervention to reduce BP variability.