Shenling Baizhu Powder Alleviates TNBS-Induced Colitis in Rats by Improving Intestinal Epithelial Permeability and Inhibiting Inflammation Through the TLR5/MyD88/NF-κB Pathway
Aim of the study: To evaluate the protective effect and mechanism of shenling baizhu powder (SBP) on TNBS-induced colitis.Methods: Rats were given TNBS to establish the model of colitis and subsequently treated with different doses of SBP or mesalamine (MES). In addition, the expression of the TLR5/...
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Frontiers Media S.A.,
2022-04-01T00:00:00Z.
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| 042 | |a dc | ||
| 100 | 1 | 0 | |a Kehan Rao |e author |
| 700 | 1 | 0 | |a Shumin Qin |e author |
| 700 | 1 | 0 | |a Shumin Qin |e author |
| 700 | 1 | 0 | |a Shumin Qin |e author |
| 700 | 1 | 0 | |a Shumin Qin |e author |
| 700 | 1 | 0 | |a Shumin Qin |e author |
| 700 | 1 | 0 | |a Yuanming Yang |e author |
| 700 | 1 | 0 | |a Kai Zhan |e author |
| 700 | 1 | 0 | |a Haomeng Wu |e author |
| 700 | 1 | 0 | |a Haomeng Wu |e author |
| 700 | 1 | 0 | |a Haomeng Wu |e author |
| 700 | 1 | 0 | |a Haomeng Wu |e author |
| 700 | 1 | 0 | |a Haomeng Wu |e author |
| 700 | 1 | 0 | |a Huan Zheng |e author |
| 700 | 1 | 0 | |a Huan Zheng |e author |
| 700 | 1 | 0 | |a Huan Zheng |e author |
| 700 | 1 | 0 | |a Huan Zheng |e author |
| 700 | 1 | 0 | |a Huan Zheng |e author |
| 700 | 1 | 0 | |a Shaogang Huang |e author |
| 700 | 1 | 0 | |a Shaogang Huang |e author |
| 700 | 1 | 0 | |a Shaogang Huang |e author |
| 700 | 1 | 0 | |a Shaogang Huang |e author |
| 700 | 1 | 0 | |a Shaogang Huang |e author |
| 700 | 1 | 0 | |a Shaogang Huang |e author |
| 245 | 0 | 0 | |a Shenling Baizhu Powder Alleviates TNBS-Induced Colitis in Rats by Improving Intestinal Epithelial Permeability and Inhibiting Inflammation Through the TLR5/MyD88/NF-κB Pathway |
| 260 | |b Frontiers Media S.A., |c 2022-04-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2022.883918 | ||
| 520 | |a Aim of the study: To evaluate the protective effect and mechanism of shenling baizhu powder (SBP) on TNBS-induced colitis.Methods: Rats were given TNBS to establish the model of colitis and subsequently treated with different doses of SBP or mesalamine (MES). In addition, the expression of the TLR5/MyD88/NF-κB signaling pathway and critical targets of the intestinal mucosal barrier was detected by immunochemical analysis techniques.Results: SBP significantly ameliorated the symptoms of TNBS-induced colitis in rats and reduced the secretion of pro-inflammatory cytokines. SBP could effectively strengthen epithelial barrier integrity in TNBS-induced colitis by increasing the secretion of mucin and tight junction and inhibiting apoptosis. Furthermore, we identified the crucial role of the TLR5/MyD88/NF-κB signaling pathway in exerting the therapeutic effect of SBP.Conclusion: The results of our study suggest that SBP has therapeutic effects on TNBS-induced colitis and potential value in treating and maintaining remission of colitis. | ||
| 546 | |a EN | ||
| 690 | |a shenling baizhu powder | ||
| 690 | |a intestinal barrier | ||
| 690 | |a MUC2 | ||
| 690 | |a ulcerative colitis | ||
| 690 | |a TLR5 | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 13 (2022) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2022.883918/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/ccc9cc74713c49ee98e986e5f8eceef5 |z Connect to this object online. |