Doxycycline and hydroxypropyl-β-cyclodextrin complex in poloxamer thermal sensitive hydrogel for ophthalmic delivery

• Main Authors: Zi-xin He (Author), Zhou-hua Wang (Author), Hao-hao Zhang (Author), Xin Pan (Author), Wen-ru Su (Author), Dan Liang (Author), Chuan-bin Wu (Author)
• Format: Book
• Published: Elsevier, 2011-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study aimed to prepare a chemically and physically stable formulation of doxycycline (Doxy) in an in situ thermally sensitive hydrogel for ophthalmic delivery. An inclusion complex of Doxy and hydroxypropyl-β-cyclodextrin (HP-β-CD) was first developed to increase the stability of Doxy in...