Subsequent Pregnancy after Preterm Prelabor Rupture of Membranes before 27 Weeks' Gestation

• Main Authors: Jantien L. van der Heyden (Author), Sander M. J. van Kuijk (Author), David P. van der Ham (Author), Kim J. B. Notten (Author), Timothy Janssen (Author), Jan G. Nijhuis (Author), Christine Willekes (Author), Martina Porath (Author), Joris A. van der Post (Author), Feico Halbertsma (Author), Eva Pajkrt (Author), Ben Willem J. Mol (Author)
• Format: Book
• Published: Thieme Medical Publishers, Inc., 2013-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2157-6998; 2157-7005; 10.1055/s-0033-1353389
• Keywords: preterm rupture of membranes; recurrence; preterm birth; Gynecology and obstetrics; RG1-991
• Source: American Journal of Perinatology Reports, Vol 03, Iss 02, Pp 113-118 (2013)

Abstract Objective Midtrimester preterm prelabor rupture of membranes (PPROM) has a high rate of neonatal mortality and morbidity. The aim of this study was to study outcomes of subsequent pregnancies after a pregnancy with PPROM before 27 weeks' gestation. Study Design Retrospective study of subsequent pregnancies of women who suffered PPROM before 27 weeks' gestation from 1994 to 2009. The main outcome measure was the risk of recurrence of PPROM before 27 weeks' gestation. The authors also studied preterm birth and pregnancy outcome in the subsequent pregnancy. Finally, they assessed associative factors for subsequent premature delivery. Results They identified 307 patients, of whom 118 women had a subsequent pregnancy. Of 99 women with complete outcome data, 9 women (9%) had PPROM before 27 weeks' gestation in a subsequent pregnancy and 35 women (35%) had a preterm delivery. In 58 (59%) of pregnancies no major complications occurred. They found three associative factors for premature delivery in a subsequent pregnancy: negative vaginal culture for Group B streptococcus, increasing maternal age and early gestational age at PPROM in the index pregnancy. Conclusions Women with PPROM before 27 weeks have a 9% recurrence risk of early PPROM and a risk of 35% of having a preterm delivery in a subsequent pregnancy.