IL-7 producing immunotherapy improves ex vivo T cell functions of immunosenescent patients, especially post hip fracture

• Main Authors: Chrystel Marton (Author), Alix Minaud (Author), Charles-Antoine Coupet (Author), Manon Chauvin (Author), Jamila Dhiab (Author), Hélène Vallet (Author), Jacques Boddaert (Author), Nadine Kehrer (Author), Bérangère Bastien (Author), Geneviève Inchauspe (Author), Luc Barraud (Author), Delphine Sauce (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Following acute stress such as trauma or sepsis, most of critically ill elderly patients become immunosuppressed and susceptible to secondary infections and enhanced mortality. We have developed a virus-based immunotherapy encoding human interleukin-7 (hIL-7) aiming at restoring both innate an adapt...