Nutritional status at age 1 year in patients born with esophageal atresia: A population-based, prospective cohort study

• Main Authors: Suzanne Depoortere (Author), Alexandre Lapillonne (Author), Rony Sfeir (Author), Arnaud Bonnard (Author), Thomas Gelas (Author), Nicoleta Panait (Author), Pierre-Yves Rabattu (Author), Audrey Guignot (Author), Thierry Lamireau (Author), Sabine Irtan (Author), Edouard Habonimana (Author), Anne Breton (Author), Virginie Fouquet (Author), Hossein Allal (Author), Frédéric Elbaz (Author), Isabelle Talon (Author), Aline Ranke (Author), Michel Abely (Author), Jean-Luc Michel (Author), Joséphine Lirussi Borgnon (Author), Philippe Buisson (Author), Françoise Schmitt (Author), Hubert Lardy (Author), Thierry Petit (Author), Yann Chaussy (Author), Corinne Borderon (Author), Guillaume Levard (Author), Clara Cremillieux (Author), Cécilia Tolg (Author), Jean Breaud (Author), Olivier Jaby (Author), Céline Grossos (Author), Philine De Vries (Author), Myriam Arnould (Author), Cécile Pelatan (Author), Stephan Geiss (Author), Christophe Laplace (Author), Maéva Kyheng (Author), Audrey Nicolas (Author), Madeleine Aumar (Author), Frédéric Gottrand (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2296-2360; 10.3389/fped.2022.969617
• Keywords: undernutrition; stunting; catch-up; growth; prematurity; small for gestational age; Pediatrics; RJ1-570
• Source: Frontiers in Pediatrics, Vol 10 (2022)

ObjectiveDespite recent progress in caring for patients born with esophageal atresia (EA), undernutrition and stunting remain common. Our study objective was to assess nutritional status in the first year after birth with EA and to identify factors associated with growth failure.Study designWe conducted a population-based study of all infants born in France with EA between 2010 and 2016. Through the national EA register, we collected prenatal to 1 year follow-up data. We used body mass index and length-for-age ratio Z scores to define patients who were undernourished and stunted, respectively. Factors with P < 0.20 in univariate analyses were retained in a logistic regression model.ResultsAmong 1,154 patients born with EA, body mass index and length-for-age ratio Z scores at 1 year were available for about 61%. Among these, 15.2% were undernourished and 19% were stunted at the age of 1 year. There was no significant catch-up between ages 6 months and 1 year. Patients born preterm (41%), small for gestational age (17%), or with associated abnormalities (55%) were at higher risk of undernutrition and stunting at age 1 year (P < 0.05). Neither EA type nor surgical treatment was associated with growth failure.ConclusionUndernutrition and stunting are common during the first year after birth in patients born with EA. These outcomes are significantly influenced by early factors, regardless of EA type or surgical management. Identifying high-risk patient groups with EA (i.e., those born preterm, small for gestational age, and/or with associated abnormalities) may guide early nutritional support strategies.