Spectrophotometric Determination of Bromhexine Hydrochloride by Azo-Dye Formation Reaction
ABSTRACT<br /> A spectrophotometric method for the assay of trace amounts of bromhexine-HCl based on the reaction of bromhexine-HCl with nitrite ion to form the corresponding diazonium salt followed by coupling reaction with pyrogallol in a acidic medium to form a stable and a soluble yellow a...
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| Main Authors: | , |
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| Format: | Book |
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College of Education for Pure Sciences,
2009-03-01T00:00:00Z.
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| Summary: | ABSTRACT<br /> A spectrophotometric method for the assay of trace amounts of bromhexine-HCl based on the reaction of bromhexine-HCl with nitrite ion to form the corresponding diazonium salt followed by coupling reaction with pyrogallol in a acidic medium to form a stable and a soluble yellow azo dye with maximum absorption at 387 nm. Beer's law is obeyed in the concentration range of 20-280g of bromhexine-HCl in a final volume of 25 ml (0.8- 11.2 ppm) with a molar absorptivity of 1.031104 L.mol-1.cm-1, a relative error of -0.36 to +0.72 % and <br /> a relative standard deviation of 1.07 to 1.72 %, depending on the concentration level of bromhexine-HCl. The method has been successfully applied for the assay of bromhexine-HCl in various pharmaceutical preparations. |
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| Item Description: | 1812-125X 2664-2530 10.33899/edusj.2009.57438 |