Unleashing the mysterious link between COVID-19 and a famous childhood vasculitis: Kawasaki disease
Abstract Background Coronavirus disease 2019 (COVID-19) emerged as a small outbreak in Wuhan rapidly progressing into the deadliest pandemic since the Spanish flu of 1918. The disease was deemed trivial in children, until the reporting, few days ago, of an emerging pediatric multi-inflammatory syndr...
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SpringerOpen,
2020-07-01T00:00:00Z.
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| 700 | 1 | 0 | |a Aisha Said AbdelAzeam |e author |
| 700 | 1 | 0 | |a Aya Ayad |e author |
| 700 | 1 | 0 | |a Aya Yasser Kamel |e author |
| 700 | 1 | 0 | |a Ayah Khalil |e author |
| 700 | 1 | 0 | |a Basma Kotb |e author |
| 700 | 1 | 0 | |a Dina Waheed |e author |
| 700 | 1 | 0 | |a Esraa Menshawey |e author |
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| 700 | 1 | 0 | |a Lama El Wakil |e author |
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| 700 | 1 | 0 | |a Mariem Badr Arsanyous |e author |
| 700 | 1 | 0 | |a Meryam El Shershaby |e author |
| 700 | 1 | 0 | |a Mina Mansour |e author |
| 700 | 1 | 0 | |a Mirette Ashraf |e author |
| 700 | 1 | 0 | |a Nada Hafez |e author |
| 700 | 1 | 0 | |a Nadeen Mohamed Abuzeid |e author |
| 700 | 1 | 0 | |a Noheir Mahmoud-Nashaat AbdElSalam |e author |
| 700 | 1 | 0 | |a Nouran Gamal Hafez |e author |
| 700 | 1 | 0 | |a Nourhan Youssef |e author |
| 700 | 1 | 0 | |a Rafeef Hozaien |e author |
| 700 | 1 | 0 | |a Rana Saeed |e author |
| 700 | 1 | 0 | |a Dina Kamel |e author |
| 700 | 1 | 0 | |a Manal Ahmed AbdelHameed |e author |
| 700 | 1 | 0 | |a Salma Ali |e author |
| 245 | 0 | 0 | |a Unleashing the mysterious link between COVID-19 and a famous childhood vasculitis: Kawasaki disease |
| 260 | |b SpringerOpen, |c 2020-07-01T00:00:00Z. | ||
| 500 | |a 10.1186/s43054-020-00029-9 | ||
| 500 | |a 2090-9942 | ||
| 520 | |a Abstract Background Coronavirus disease 2019 (COVID-19) emerged as a small outbreak in Wuhan rapidly progressing into the deadliest pandemic since the Spanish flu of 1918. The disease was deemed trivial in children, until the reporting, few days ago, of an emerging pediatric multi-inflammatory syndrome mimicking Kawasaki disease (KD). Main body This report reveals that coronaviridae were implicated in induction of several post-infectious vasculitides, namely, KD, AHEI, and HSP. This occurs in genetically susceptible individuals to vascular inflammation. Shared genetic susceptibilities between KD and CoV include genes encoding for CD 40, HLAB-15:03, and ACE. This leads to augmented inflammation with hypersecretion of cytokines especially IL-6. Conclusion The revealed relationships between KD and CoV can help to predict the risk of KD in COVID-19 patients through screening levels of upregulated cytokines. It might also signify that classic treatment of KD with IVIG might need to be replaced with anti-cytokine therapy in COVID-19 patients. | ||
| 546 | |a EN | ||
| 690 | |a COVID-19 | ||
| 690 | |a Kawasaki disease, Shared genetic and inflammatory pathways | ||
| 690 | |a Upregulated inflammation | ||
| 690 | |a Pediatrics | ||
| 690 | |a RJ1-570 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Egyptian Pediatric Association Gazette, Vol 68, Iss 1, Pp 1-7 (2020) | |
| 787 | 0 | |n http://link.springer.com/article/10.1186/s43054-020-00029-9 | |
| 787 | 0 | |n https://doaj.org/toc/2090-9942 | |
| 856 | 4 | 1 | |u https://doaj.org/article/cd34f067de984c4ebbcdaa4f7cc4ec6c |z Connect to this object online. |