Non-viral in vivo cytidine base editing in hepatocytes using focused ultrasound targeted microbubbles

• Main Authors: Cynthia D. Anderson (Author), Jennifer Ataam Arthur (Author), Yuan Zhang (Author), Nike Bharucha (Author), Ioannis Karakikes (Author), Ralph V. Shohet (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CRISPR-Cas9-based genome editing technologies, such as base editing, have the potential for clinical translation, but delivering nucleic acids into target cells in vivo is a major obstacle. Viral vectors are widely used but come with safety concerns, while current non-viral methods are limited by lo...