A case of severe uterine arteriovenous malformation treated with danazol followed by a transarterial embolization of unilateral uterine and ovarian arteries

Uterine arteriovenous malformation (AVM) is a potentially life-threatening condition characterized by abrupt and profuse uterine bleeding from abnormal connections between arteries and veins in the myometrium. It is commonly associated with prior pregnancy or uterine trauma. We present a case of sev...

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Main Authors: Hiroyuki Yazawa (Author), Syu Soeda (Author), Tsuyoshi Hiraiwa (Author), Masayo Takaiwa (Author), Keiya Fujimori (Author)
Format: Book
Published: Wolters Kluwer Medknow Publications, 2015-11-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Hiroyuki Yazawa  |e author 
700 1 0 |a Syu Soeda  |e author 
700 1 0 |a Tsuyoshi Hiraiwa  |e author 
700 1 0 |a Masayo Takaiwa  |e author 
700 1 0 |a Keiya Fujimori  |e author 
245 0 0 |a A case of severe uterine arteriovenous malformation treated with danazol followed by a transarterial embolization of unilateral uterine and ovarian arteries 
260 |b Wolters Kluwer Medknow Publications,   |c 2015-11-01T00:00:00Z. 
500 |a 2213-3070 
500 |a 10.1016/j.gmit.2015.10.001 
520 |a Uterine arteriovenous malformation (AVM) is a potentially life-threatening condition characterized by abrupt and profuse uterine bleeding from abnormal connections between arteries and veins in the myometrium. It is commonly associated with prior pregnancy or uterine trauma. We present a case of severe uterine AVM treated with danazol and transarterial embolization (TAE). A 38-year-old patient with a history of two abortions and a myomectomy was referred to our hospital for intermittent massive uterine bleeding. She was diagnosed with uterine AVM by transvaginal color Doppler ultrasonography and helical computed tomography (CT). Diagnostic three-dimensional CT (3D-CT) angiography clearly demonstrated hypervascular tangles of uterine vessels, feeding arteries, remarkably dilated draining veins, as well as early filling of the internal iliac vein and the inferior vena cava, indicating massive arteriovenous shunting in the uterus. Danazol was administrated for 10 months to reduce the shunting of the uterine AVM before TAE with N-butyl-cyanoacrylate of the left ovarian artery and left uterine artery was successfully performed. After the procedure, we confirmed that shunting through the uterine AVM was markedly reduced. The patient has not experienced any severe uterine bleeding since the treatment. 
546 |a EN 
690 |a 3D-CT angiography 
690 |a color Doppler ultrasonography 
690 |a danazol 
690 |a transarterial embolization 
690 |a uterine arteriovenous malformation 
690 |a Gynecology and obstetrics 
690 |a RG1-991 
655 7 |a article  |2 local 
786 0 |n Gynecology and Minimally Invasive Therapy, Vol 4, Iss 4, Pp 149-153 (2015) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S2213307015001446 
787 0 |n https://doaj.org/toc/2213-3070 
856 4 1 |u https://doaj.org/article/cd6e18cdfd9b41029cf2fa630be5d02d  |z Connect to this object online.