Frequency of Hepatitis A virus as a cause of anicteric hepatitis in children under 5 years: a common yet under-recognized cause

• Main Authors: Noha A. Yassin (Author), Salma Z. El-Houchi (Author), Sarah F. Abd El-Shafy (Author), Noha S. Soliman (Author), Mohamed A. Elmonem (Author), Nehal El-Koofy (Author)
• Format: Book
• Published: SpringerOpen, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.1186/s43054-022-00134-x; 2090-9942
• Keywords: Anicteric; Hepatitis A; Developing countries; Anti-HAV IgM; Pediatrics; RJ1-570
• Source: Egyptian Pediatric Association Gazette, Vol 70, Iss 1, Pp 1-6 (2022)

Abstract Background Hepatitis A is the most common form of acute viral hepatitis in developing countries. In children < 6 years of age, most infections are asymptomatic, and if illness does occur, it is usually anicteric. This study aimed to determine the frequency of HAV in Egyptian children under 5 years presenting with gastroenteritis-like manifestations and to associate the frequency of HAV with social, demographic, and various risk factors. Results Among 450 children aged from 6 months to 5 years of both sexes, presenting with gastroenteritis-like manifestations and anicteric hepatitis, 200/450 children had elevated transaminases (ALT, AST) and were recruited in the study. A total number of 24 (12%) out of 200 children were found to have HAV IgM antibodies. Lower maternal and paternal education, poor sanitary and hygienic conditions, crowding, contaminated water, and lack of sanitary facilities were significantly higher in HAV-positive group (p-value < 0.05). ALT and AST were significantly higher in HAV IgM-positive group (p-value < 0.01). Conclusion HAV infection is common in Egyptian children with gastroenteritis-like manifestations and anicteric hepatitis. Hepatitis A is a vaccine-preventable disease.