Non-canonical Notch Signaling Regulates Actin Remodeling in Cell Migration by Activating PI3K/AKT/Cdc42 Pathway

• Main Authors: Lei Liu (Author), Lin Zhang (Author), Shuo Zhao (Author), Xu-Yang Zhao (Author), Peng-Xiang Min (Author), Ya-Dong Ma (Author), Yue-Yuan Wang (Author), Yan Chen (Author), Si-Jie Tang (Author), Yu-Jie Zhang (Author), Jun Du (Author), Luo Gu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor cell migration is a critical step in cancer metastasis. Over-activated Notch pathway can promote the migration of cancer cells, especially in the breast cancer. However, the underlying mechanism of non-canonical Notch signaling in modulating the migration has not yet been clearly characterized...