Antithrombin III Alleviates Myocardial Ischemia/Reperfusion Injury by Inhibiting Excessive Autophagy in a Phosphoinositide 3-Kinase/Akt-Dependent Manner

• Main Authors: Kai-yu Huang (Author), Jiao-ni Wang (Author), Ying-ying Zhou (Author), Shao-ze Wu (Author), Lu-yuan Tao (Author), Yang-pei Peng (Author), Jia-qun Que (Author), Yang-jing Xue (Author), Kang-ting Ji (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Autophagy is fundamental to myocardial ischemia/reperfusion (I/R) injury. Antithrombin III (AT) has been shown to protect cardiomyocytes against I/R injury; however, it is unknown whether it modulates autophagy. The objective of this study was to investigate whether AT regulates autophagy during I/R...