Boron delivery for boron neutron capture therapy targeting a cancer-upregulated oligopeptide transporter

• Main Authors: Junji Miyabe (Author), Ryuichi Ohgaki (Author), Keijiro Saito (Author), Ling Wei (Author), Lili Quan (Author), Chunhuan Jin (Author), Xingming Liu (Author), Suguru Okuda (Author), Shushi Nagamori (Author), Hiroshi Ohki (Author), Kazuo Yoshino (Author), Hidenori Inohara (Author), Yoshikatsu Kanai (Author)
• Format: Book
• Published: Elsevier, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Boron neutron capture therapy (BNCT) is a radiotherapy utilizing the neutron capture and nuclear fission reaction of 10B taken up into tumor cells. The most commonly used boron agent in BNCT, p-borono-l-phenylalanine (BPA), is accumulated in tumors by amino acid transporters upregulated in tumor cel...