Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids

• Main Authors: Jian Bai (Author), Rong Mu (Author), Man Dou (Author), Daojiang Yan (Author), Bingyu Liu (Author), Qian Wei (Author), Jun Wan (Author), Yi Tang (Author), Youcai Hu (Author)
• Format: Book
• Published: Elsevier, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epigenetic modifications have been proved to be a powerful way to activate silent gene clusters and lead to diverse secondary metabolites in fungi. Previously, inactivation of a histone H3 deacetylase in Calcarisporium arbuscula had led to pleiotropic activation and overexpression of more than 75% o...