Increased Transendothelial Transport of CCL3 Is Insufficient to Drive Immune Cell Transmigration through the Blood-Brain Barrier under Inflammatory Conditions In Vitro

• Main Authors: Maxime De Laere (Author), Carmelita Sousa (Author), Megha Meena (Author), Roeland Buckinx (Author), Jean-Pierre Timmermans (Author), Zwi Berneman (Author), Nathalie Cools (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Many neuroinflammatory diseases are characterized by massive immune cell infiltration into the central nervous system. Identifying the underlying mechanisms could aid in the development of therapeutic strategies specifically interfering with inflammatory cell trafficking. To achieve this, we impleme...