Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice

• Egile Nagusiak: Brecht Attema (Egilea), Aafke W.F. Janssen (Egilea), Deborah Rijkers (Egilea), Evert M. van Schothorst (Egilea), Guido J.E.J. Hooiveld (Egilea), Sander Kersten (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2022-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Objective: Perfluoroalkyl substances (PFAS) are man-made chemicals with demonstrated endocrine-disrupting properties. Exposure to perfluorooctanoic acid (PFOA) has been linked to disturbed metabolism via the liver, although the exact mechanism is not clear. Moreover, information on the metabolic eff...