Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice

• Hauptverfasser: Brecht Attema (VerfasserIn), Aafke W.F. Janssen (VerfasserIn), Deborah Rijkers (VerfasserIn), Evert M. van Schothorst (VerfasserIn), Guido J.E.J. Hooiveld (VerfasserIn), Sander Kersten (VerfasserIn)
• Format: Buch
• Veröffentlicht: Elsevier, 2022-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Objective: Perfluoroalkyl substances (PFAS) are man-made chemicals with demonstrated endocrine-disrupting properties. Exposure to perfluorooctanoic acid (PFOA) has been linked to disturbed metabolism via the liver, although the exact mechanism is not clear. Moreover, information on the metabolic eff...