Xanthine oxidase and aldehyde oxidase contribute to allopurinol metabolism in rats

• Main Authors: Yoshitaka Tayama (Author), Kazumi Sugihara (Author), Seigo Sanoh (Author), Katsushi Miyake (Author), Shigeyuki Kitamura (Author), Shigeru Ohta (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Allopurinol is used to treat hyperuricemia and gout. It is metabolized to oxypurinol by xanthine oxidase (XO), and aldehyde oxidase (AO). Allopurinol and oxypurinol are potent XO inhibitors that reduce the plasma uric acid levels. Although oxypurinol levels show large inter-indiv...