Dehydroepiandrosterone Cocrystals with Improved Solubility and Bioavailability

• Main Authors: Yihua Jiang (Author), Yinxiang Cheng (Author), Mengyuan Xia (Author), Bingrui Zhang (Author), Qiaoce Ding (Author), Liye Lu (Author), Jian-Rong Wang (Author), Xuefeng Mei (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dehydroepiandrosterone (DHEA) is an FDA-approved food supplement used as an assisted reproductive sex hormone. The bioavailability is severely limited by its poor solubility (23 µg/mL). Herein, we aimed to modulate its solubility through cocrystallization. Eight cocrystals of DHEA with pyrocatechol...